Article

Enhancer-dependence of gene expression increases with developmental age

2019-06-21

Abstract excerpt

<h4>Summary</h4> How overall principles of gene regulation (the “logic”) may change during ontogeny is largely unexplored. We compared transcriptomic, epigenomic and topological profiles in embryonic (EryP) and adult (EryD) erythroblasts. Despite reduced chromatin accessibility compared to EryP, distal chromatin of EryD is enriched in H3K27ac, Gata1 and Myb occupancy. In contrast to EryP-specific genes, which exh...

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Literature Corpus work: 3674d845-a1b3-5673-b113-8596eec1660d
DOI: 10.1101/678334

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