Article

Epigenomic and 3D genome architecture in naïve and primed human embryonic stem cell states

2017-08-26

Abstract excerpt

<h4>ABSTRACT</h4> During mammalian embryogenesis changes in morphology and gene expression are concurrent with epigenomic reprogramming. Using human embryonic stem cells representing the pre-implantation blastocyst (naïve) and post-implantation epiblast (primed), our data demonstrate that a substantial portion of known human enhancers are pre-marked by H3K4me1 in naïve cells, providing an enhanced open chromatin...

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Literature Corpus work: 6a09d2af-18bb-57bd-9b00-4f1a8729fe07
DOI: 10.1101/181123

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