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Dynamic Transcriptional and Epigenetic Regulation of Human Epidermal Keratinocyte Differentiation

1 Apr 2016

Abstract excerpt

Human skin is maintained by the differentiation and maturation of interfollicular stem and progenitors cells. We used DeepCAGE, genome-wide profiling of histone modifications and retroviral integration analysis, to map transcripts, promoters, enhancers, and super-enhancers (SEs) in prospectively isolated keratinocytes and transit-amplifying progenitors, and retrospectively defined keratinocyte stem cells. We show...

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PMID: 27050947
DOI: 10.1016/j.stemcr.2016.03.003

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