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Article

FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation

1 Jul 2019

Abstract excerpt

Transcriptional regulatory mechanisms of lineage priming in embryonic development are largely uncharacterized because of the difficulty of isolating transient progenitor populations. Directed differentiation of human pluripotent stem cells (hPSCs) combined with gene editing provides a powerful system to define precise temporal gene requirements for progressive chromatin changes during cell fate transitions. Here,...

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PMID: 31291575
DOI: 10.1016/j.celrep.2019.06.034

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