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Article

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo.

Development (Cambridge, England) - 1 Apr 2017

Simon Claire S, Downes Damien J, Gosden Matthew E, Telenius Jelena, Higgs Douglas R, Hughes Jim R, Costello Ita, Bikoff Elizabeth K, Robertson Elizabeth J

Abstract excerpt

The T-box transcription factor (TF) Eomes is a key regulator of cell fate decisions during early mouse development. The cis-acting regulatory elements that direct expression in the anterior visceral endoderm (AVE), primitive streak (PS) and definitive endoderm (DE) have yet to be defined. Here, we identified three gene-proximal enhancer-like sequences (PSE_a, PSE_b and VPE) that faithfully activate...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28174238
DOI: 10.1242/dev.147322
PMCID: PMC5399628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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