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Article

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors

17 Nov 2021

Abstract excerpt

FOXA pioneer transcription factors (TFs) associate with primed enhancers in endodermal organ precursors. Using a human stem cell model of pancreas differentiation, we here discover that only a subset of pancreatic enhancers is FOXA-primed, whereas the majority is unprimed and engages FOXA upon lineage induction. Primed enhancers are enriched for signal-dependent TF motifs and harbor abundant and strong FOXA...

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PMID: 34789735
DOI: 10.1038/s41467-021-26950-0

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