Article

A dual-phase enhancer couples progenitor maintenance and pancreatic lineage stability

2026-02-12

Abstract excerpt

Enhancers orchestrate transcriptional programs that control organ development and maintain differentiated cell states, yet how individual enhancers integrate developmental and long-term tissue maintenance logic remains poorly understood. Here, we identify a distal enhancer downstream of ptf1a (z3’-DpE) as a regulatory node coupling pancreatic development with acinar cell homeostasis in zebrafish. Deletion of z3’-...

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Literature Corpus work: 20d79d31-6019-5e56-833b-5b1456fbd9c8
DOI: 10.64898/2026.02.11.705016

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