Article

The chromatin structuring protein HMGA2 influences human subtelomere stability and cancer chemosensitivity

2019-02-08

Abstract excerpt

The transient build-up of DNA supercoiling during the translocation of replication forks threatens genome stability and is controlled by DNA topoisomerases (TOPs). This crucial process has been exploited with TOP poisons for cancer chemotherapy. However, pinpointing cellular determinants of the best clinical response to TOP poisons still remains enigmatic. Here, we present an integrated approach and demonstrate th...

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Literature Corpus work: 8c72afab-d40e-5f6a-922b-7b57b77c9e95
DOI: 10.1101/544320

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