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Article

Breaking TADs: How Alterations of Chromatin Domains Result in Disease.

Trends in genetics : TIG - 1 Apr 2016

Lupiáñez Darío G, Spielmann Malte, Mundlos Stefan

Abstract excerpt

Spatial organization is an inherent property of the vertebrate genome to accommodate the roughly 2m of DNA in the nucleus of a cell. In this nonrandom organization, topologically associating domains (TADs) emerge as a fundamental structural unit that is thought to guide regulatory elements to their cognate promoters. In this review we summarize the most recent findings about TADs and the boundary regions...

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Identifiers

PMID: 26862051
DOI: 10.1016/j.tig.2016.01.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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