Article

DNA Topoisomerase I differentially modulates R-loops across the human genome

2018-01-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Co-transcriptional R-loops are abundant non-B DNA structures in mammalian genomes. DNA Topoisomerase I (Top1) is often thought to regulate R-loop formation owing to its ability to resolve both positive and negative supercoils. How Top1 regulates R-loop structures at a global level is unknown. <h4>Results</h4> Here, we performed high-resolution strand-specific R-loop mapping...

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Literature Corpus work: 08830c6f-ac33-515f-ba57-bb3858bec820
DOI: 10.1101/257303

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