Article

Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedback

2026-03-26

Abstract excerpt

Genome-wide DNA supercoiling is closely linked to chromatin organization and gene expression, yet the mechanisms establishing genome-scale supercoiling in living cells and its functional consequences remain unclear. Here, we show that genome-wide supercoiling arises from transcription-driven asymmetric topological relaxation together with contributions from SMC complexes in human cells. During RNA polymerase elong...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 50de7435-4dd4-5c6d-9e6d-b5e27c2dc5a4
DOI: 10.64898/2026.03.26.714539

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide DNA supercoiling arises from transcription and SMC activity and mediates transcriptional negative feedbackDOI 10.64898/2026.03.26.714539Read

DNA supercoiling links transcription and chromatin architecture during human stem cell differentiationSemantic proximity Read

CpG islands act as topological sinks for transcription-induced DNA supercoilingSemantic proximity Read

Control of RNA polymerase II promoter-proximal pausing by DNA supercoilingSemantic proximity Read

Human Smc5/6 recognises transcription-generated positive DNA supercoilsSemantic proximity Read

Extruding transcription elongation loops observed in high-resolution single-cell 3D genomesSemantic proximity Read

DNA Topoisomerase I differentially modulates R-loops across the human genomeSemantic proximity Read

Human Smc5/6 recognises transcription-generated positive DNA supercoilsSemantic proximity Read

DNA-Stimulated Liquid-Liquid phase separation by eukaryotic topoisomerase ii modulates catalytic functionSemantic proximity Read

Extruding transcription elongation loops observed in high-resolution single-cell 3D genomesSemantic proximity Read

Topological regulation of the estrogen transcriptional response by ZATT-mediated inhibition of TOP2B activitySemantic proximity Read

MYC modulates TOP2A diffusion to promote substrate detection and activitySemantic proximity Read

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.Semantic proximity Read