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Article

Genome-wide analysis uncovers high frequency, strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulation

1 Jan 2013

Abstract excerpt

BACKGROUND: An emerging Hi-C protocol has the ability to probe three-dimensional (3D) architecture and capture chromatin interactions in a genome-wide scale. It provides informative results to address how chromatin organization changes contribute to disease/tumor occurrence and progression in response to stimulation of environmental chemicals or hormones. RESULTS: In this study, using MCF7 cells as a model...

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PMID: 23368971
DOI: 10.1186/1471-2164-14-70

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