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Article

Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription.

Nature communications - 13 Oct 2023

Lau Mei Sheng, Hu Zhenhua, Zhao Xiaodan, Tan Yaw Sing, Liu Jinyue, Huang Hua, Yeo Clarisse Jingyi, Leong Hwei Fen, Grinchuk Oleg V, Chan Justin Kaixuan, Yan Jie, Tee Wee-Wei

Abstract excerpt

Regulation of global transcription output is important for normal development and disease, but little is known about the mechanisms involved. DNA topoisomerase I (TOP1) is an enzyme well-known for its role in relieving DNA supercoils for enabling transcription. Here, we report a non-enzymatic function of TOP1 that downregulates RNA synthesis. This function is dependent on specific DNA-interacting residues located...

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Identifiers

PMID: 37833256
DOI: 10.1038/s41467-023-42078-9
PMCID: PMC10576097

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