Article

Control of RNA polymerase II promoter-proximal pausing by DNA supercoiling

2020-05-14

Abstract excerpt

<h4>Summary</h4> The accumulation of topological stress in the form of DNA supercoiling is inherent to the advance of RNA polymerase II (Pol II) complexes, and needs to be resolved by DNA topoisomerases to sustain productive transcriptional elongation. Topoisomerases are therefore considered general positive facilitators of transcription. Here we show that, in contrast to this general assumption, human topoisomer...

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Literature Corpus work: ba647544-49e3-59a6-b297-a465e28a92ba
DOI: 10.1101/2020.05.12.091058

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