Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.

Genome biology - 1 Nov 2021

Talon Irene, Janiszewski Adrian, Theeuwes Bart, Lefevre Thomas, Song Juan, Bervoets Greet, Vanheer Lotte, De Geest Natalie, Poovathingal Suresh, Allsop Ryan, Marine Jean-Christophe, Rambow Florian, Voet Thierry, Pasque Vincent

Abstract excerpt

BACKGROUND: Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X chromosome is inactive. Moreover, the inactive X chromosome is reactivated during development in the inner cell mass and in germ cells through X chromosome reactivation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Induced Pluripotent Stem Cells

Share to RNA-Seq

Share to Single-Cell Analysis

Share to X Chromosome

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 34724962
DOI: 10.1186/s13059-021-02518-5
PMCID: PMC8558763

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals.PMID 34724962Read ↗

Elastic dosage compensation by X-chromosome upregulation.Semantic proximity Read ↗

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC ReprogrammingSemantic proximity Read ↗

Comprehensively characterizing evolutionarily conserved differential dosage compensations of the X chromosome during development and in diseasesSemantic proximity Read ↗

Dosage compensation in the mouse balances up-regulation and silencing of X-linked genes.Semantic proximity Read ↗

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA HypomethylationSemantic proximity Read ↗

Dynamics of gene silencing during X inactivation using allele-specific RNA-seq.Semantic proximity Read ↗

Early X chromosome inactivation during human preimplantation development revealed by single-cell RNA-sequencing.Semantic proximity Read ↗

X Chromosome Dosage Modulates Multiple Molecular and Cellular Properties of Mouse Pluripotent Stem Cells Independently of Global DNA Methylation LevelsSemantic proximity Read ↗

X-chromosome dosage compensation dynamics in human early embryosSemantic proximity Read ↗

Spatio-temporal X-linked gene reactivation and site-specific retention of epigenetic silencing in the mouse germlineSemantic proximity Read ↗

Dynamic X-chromosomal reactivation enhances female brain resilienceSemantic proximity Read ↗

Regulation of X-chromosome inactivation by the X-inactivation centre.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.