Article

Dynamic X-chromosomal reactivation enhances female brain resilience

2023-06-21

Abstract excerpt

<h4>Summary</h4> While random X-chromosome inactivation in female cells of placental mammalians silences one allele of the majority of X-chromosomal genes, a considerable fraction is only incompletely and variably inactivated resulting in a tissue-specific pattern of mono- and biallelic expression. Here we used clonal human female induced pluripotent stem cells (iPSCs) allowing to trace the (in)activation status...

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Literature Corpus work: 04deaa8c-87bd-5866-905b-458609740dd7
DOI: 10.1101/2023.06.17.545424

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