Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation.

Genome biology - 25 Jan 2017

Cantone Irene, Dharmalingam Gopuraja, Chan Yi-Wah, Kohler Anne-Celine, Lenhard Boris, Merkenschlager Matthias, Fisher Amanda G

Abstract excerpt

BACKGROUND: Inactivation of one X chromosome is established early in female mammalian development and can be reversed in vivo and in vitro when pluripotency factors are re-expressed. The extent of reactivation along the inactive X chromosome (Xi) and the determinants of locus susceptibility are, however, poorly understood. Here we use cell fusion-mediated pluripotent reprograming to study human Xi reactivation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Fusion
Share to Cellular Reprogramming

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin

Share to Embryonic Stem Cells

Share to Genes, X-Linked

Share to Pluripotent Stem Cells

Share to Transcriptional Activation

Share to X Chromosome Inactivation

Source

Open in PubMed Open full text

Identifiers

PMID: 28118853
DOI: 10.1186/s13059-016-1136-4
PMCID: PMC5264468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Allele-specific analysis of cell fusion-mediated pluripotent reprograming reveals distinct and predictive susceptibilities of human X-linked genes to reactivation.PMID 28118853Read ↗

Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.Semantic proximity Read ↗

Contiguous Erosion of the Inactive X in Human Pluripotency Concludes With Global DNA HypomethylationSemantic proximity Read ↗

Epigenetic resetting of human pluripotencySemantic proximity Read ↗

X-chromosome inactivation in human iPSCs provides insight into X-regulated gene expression in autosomes.Semantic proximity Read ↗

Dynamic X-chromosomal reactivation enhances female brain resilienceSemantic proximity Read ↗

Dynamic Erasure of Random X-Chromosome Inactivation during iPSC ReprogrammingSemantic proximity Read ↗

Spatio-temporal X-linked gene reactivation and site-specific retention of epigenetic silencing in the mouse germlineSemantic proximity Read ↗

Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiationSemantic proximity Read ↗

Early reactivation of clustered genes on the inactive X chromosome during somatic cell reprogramming.Semantic proximity Read ↗

X Chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming.Semantic proximity Read ↗

Dynamic allele usage of X-linked genes ameliorates neurodevelopmental disease phenotypes in brain organoids.Semantic proximity Read ↗

X-inactivation states of single cell transcriptomes reveal cellular phylogenies in human femalesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.