Article

Erosion of X-Chromosome Inactivation in female hiPSCs is heterogeneous and persists during differentiation

2024-03-15

Abstract excerpt

<h4>ABSTRACT</h4> During culture, female human pluripotent stem cells (hPSCs), including human induced PSCs (hiPSCs) exhibit a propensity for erosion of X-chromosome inactivation (XCI). This phenomenon is characterized by the loss of XIST RNA expression and reactivation of a subset of X-linked genes from the inactive X chromosome (Xi). XCI erosion, despite its common occurrence, is often overlooked by the stem ce...

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Literature Corpus work: 58a883a3-ed1e-5bff-a2df-b44296cf9ce7
DOI: 10.1101/2024.03.15.585169

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