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Article

Human X chromosome inactivation and reactivation: implications for cell reprogramming and disease.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 5 Nov 2017

Cantone Irene, Fisher Amanda G

Abstract excerpt

X-chromosome inactivation (XCI) is an exemplar of epigenetic regulation that is set up as pluripotent cells differentiate. Once established, XCI is stably propagated, but can be reversed in vivo or by pluripotent reprogramming in vitro Although reprogramming provides a useful model for inactive X (Xi) reactivation in mouse, the relative instability and heterogeneity of human embryonic stem (ES) cells and induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28947657
DOI: 10.1098/rstb.2016.0358
PMCID: PMC5627160

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