Article

Microvascular collapse establishes a hypoxic niche that sabotages microglial autophagic clearance in Parkinson's disease

2026-06-16

Abstract excerpt

<title>Abstract</title> <p> Microglial hyper-activation drives Parkinson's disease (PD) progression, yet the upstream microenvironmental cues that sustain this neurotoxic state remain elusive. While α-synuclein (α-Syn) aggregation is a primary trigger, aging and PD are also characterized by severe microvascular degradation. However, the exact crosstalk between vascular-driven hypoxia and protein toxicity in micr...

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Literature Corpus work: 7351638b-7b4a-5d43-bd91-f05cd66590d7
DOI: 10.21203/rs.3.rs-9888982/v1

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