Article

Systematic screening identifies elevated neurovascular BCL-XL in Parkinson’s disease

2026-05-06

Abstract excerpt

<h4>Background</h4> Vascular cells are emerging as active players in Parkinson’s disease (PD), yet their molecular contribution to α-Synuclein (α-Syn) pathology remains undefined. Here, we show that human brain pericytes respond in a distinct manner to unique α-Syn strains, with systematic validation identifying BCL-XL as a potential regulator of the neurovascular unit in PD. <h4>Methods</h4> Primary human brain...

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Literature Corpus work: 2e3cebd5-3229-583d-bf43-5f19a0d10895
DOI: 10.64898/2026.05.03.722488

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