Article

CNTNAP4 partial deficiency exacerbates α -synuclein pathology through astrocyte–microglia interplay

2022-03-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Parkinson’s disease (PD) is a common progressive neurodegenerative movement disorder, which is characterized by dopaminergic (DA) neuron death and the aggregation of neurotoxic α-synuclein. <italic>CNTNAP4</italic>, a risk gene of autism, has been implicated to participate in DA neuron degeneration in PD pathogenesis. However, the role of CNTNAP4 in α-synuclein pa...

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Literature Corpus work: 2001b32e-a027-50e6-bc53-c1146219d7ae
DOI: 10.21203/rs.3.rs-1380491/v1

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