Article

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissue

2025-12-13

Abstract excerpt

<title>Abstract</title> <p> Background Parkinson’s disease (PD) is a neurodegenerative disease marked by a progressive loss of dopaminergic neurons in the substantia nigra <italic>pars compacta</italic> (SNpc) and formation of misfolded protein aggregates. A growing body of research has implicated glial cell dysfunction in PD etiology, including the concentration of activated glial cells around protein aggrega...

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Literature Corpus work: c2581150-e6a2-5904-a716-c0db9eeafcd9
DOI: 10.21203/rs.3.rs-8281185/v1

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