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Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

18 Aug 2025

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD) collectively represent the majority of dementia cases worldwide. While these subtypes share clinical, genetic, and pathological features, their transcriptomic similarities and differences remain poorly understood. METHODS: We applied single-nucleus RNA-sequencing (snRNA-seq) to prefrontal cortex samples...

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PMID: 40826098
DOI: 10.1186/s13073-025-01519-4

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