Article

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

2025-08-28

Abstract excerpt

<h4>SUMMARY</h4> Parkinson’s disease (PD) is characterised by insoluble α-synuclein (αSyn) aggregates in Lewy bodies (LBs) within the substantia nigra, with cortical pathology appearing as the disease progresses. Late-stage LB deposition, cellular stress, and neuronal loss obscure disease-driving events, we therefore performed multi-regional transcriptomic and aggregate profiling in early-midstage PD brains (Braa...

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Literature Corpus work: d51989e4-5896-5615-a31d-14c0b99915f2
DOI: 10.1101/2025.08.25.671921

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