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Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutation

2025-10-26

Abstract excerpt

<title>Abstract</title> <p>Microglia are the primary resident immune cells of the brain, playing both protective and deleterious roles in neurological diseases, which make them an enticing therapeutic target. Here we developed a Neural Microglia Integrated Multicellular iPSC-derived Cultured Spheroids (NeuroMIMICS) system, that enables measurements of both neural network activity and immune responses using human...

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Literature Corpus work
b69e01a0-6056-56d5-8e2b-f150840ecabe
DOI
10.21203/rs.3.rs-7753275/v1
Open publication

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Microglia integrated neural spheroids enable neuroinflammatory responses and correct network dysfunction induced by alpha-synuclein mutationDOI 10.21203/rs.3.rs-7753275/v1
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