Article

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissue

2025-11-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Parkinson’s disease (PD) is a neurodegenerative disease marked by a progressive loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) and formation of misfolded protein aggregates. A growing body of research has implicated glial cell dysfunction in PD etiology, including the concentration of activated glial cells around protein aggregates in post-mortem...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9bfdd666-7599-5168-a148-7768e613a8d7
DOI: 10.1101/2025.11.13.687853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissueDOI 10.1101/2025.11.13.687853Read

Single nuclear RNA sequencing shows altered microglial and astrocytic functions in post-mortem Parkinson’s disease tissueSemantic proximity Read

RNA- and ATAC-sequencing Reveals a Unique <i>CD83+</i> Microglial Population Focally Depleted in Parkinson’s DiseaseSemantic proximity Read

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypesSemantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read

Glial multicellular programs reveal distinct patient stratification in Parkinson's diseaseSemantic proximity Read

Single-nucleus and spatial transcriptomic analysis identified molecular features of neuronal heterogeneity and distinct glial responses in Parkinson’s diseaseSemantic proximity Read

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathologySemantic proximity Read

Single-nucleus and spatial transcriptomic analysis identified molecular features of neuronal heterogeneity and distinct glial responses in Parkinson’s diseaseSemantic proximity Read

A Transcriptomic Roadmap of Parkinson’s Disease Progression at Single Cell ResolutionSemantic proximity Read

Single-cell transcriptomic and proteomic analysis of Parkinson’s disease BrainsSemantic proximity Read

Unveiling microglial heterogeneity from single-cell transcriptomics in neurodegenerative diseasesSemantic proximity Read

A review of genome‐wide transcriptomics studies in Parkinson's diseaseSemantic proximity Read