Article

Single-cell Spatial Transcriptomics Reveals Disease-specific Microenvironmental Niches in Neurodegeneration and COVID-19

2025-03-17

Abstract excerpt

<h4>ABSTRACT</h4> Neurodegenerative diseases and infections can produce lasting effects on brain function, yet the spatial molecular mechanisms underlying these changes remain poorly understood. Here, we present high-resolution spatial transcriptomics of 40 postmortem brain samples from patients with Parkinson’s disease, frontotemporal dementia, dementia with Lewy bodies, and severe COVID-19. Analyzing over 1.5 m...

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Literature Corpus work: a1759202-fae3-53d9-b30f-b499124dbd4f
DOI: 10.1101/2025.03.15.643484

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