Article

Tracing the Transitions from Pluripotency to Germ Cell Fate with CRISPR Screening

2018-02-22

Abstract excerpt

<h4>ABSTRACT</h4> Early mammalian development entails a series of cell fate transitions that includes transit through naïve pluripotency to post-implantation epiblast. This subsequently gives rise to primordial germ cells (PGC), the founding population of the germline lineage. To investigate the gene regulatory networks that control these critical cell fate decisions, we developed a compound-reporter system to tr...

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Literature Corpus work: 7329238f-9d41-572c-88bf-16fa4fd98622
DOI: 10.1101/269811

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