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Article

Of Mice and Men: In Vivo and In Vitro Studies of Primordial Germ Cell Specification.

Seminars in reproductive medicine - 1 Mar 2017

Kumar Deepti Lava, DeFalco Tony

Abstract excerpt

Specification of mouse primordial germ cells (PGCs), the precursors of sperm and eggs, involves three major molecular events: repression of the somatic program, reacquisition of pluripotency, and reprogramming to a unique epigenetic ground state. Gene knockout studies in mouse models, along with global transcriptome analyses, have revealed the key signaling pathways and transcription factors essential for PGC...

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Source

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Identifiers

PMID: 28278531
DOI: 10.1055/s-0037-1599085
PMCID: PMC5460914

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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