Article

Differential repression of <i>Otx2</i> underlies the capacity of NANOG and ESRRB to induce germline entry

2021-06-14

Abstract excerpt

<h4>Summary</h4> Primordial germ cells (PGCs) are induced in the embryo by signals, including BMP emanating from extra-embryonic ectoderm, that act on cells in the post-implantation epiblast. PGC development can be recapitulated in vitro through the exposure of epiblast-like cells (EpiLCs) to appropriate cytokines, resulting in differentiation into PGC-like cells (PGCLCs). Interestingly, the requirement for cyto...

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Literature Corpus work: ec142f3f-3e6b-5600-8eb4-a0b1c7def720
DOI: 10.1101/2021.06.14.448276

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