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Article

Germline development in rat revealed by visualization and deletion of Prdm14

1 Jan 2020

Abstract excerpt

Primordial germ cells (PGCs), the founder cells of the germline, are specified in pre-gastrulating embryos in mammals, and subsequently migrate towards gonads to mature into functional gametes. Here, we investigated PGC development in rats, by genetically modifying Prdm14, a unique marker and a critical PGC transcriptional regulator. We trace PGC development in rats, for the first time, from specification until...

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PMID: 32001439
DOI: 10.1242/dev.183798

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