Article

Cooperative genetic networks drive a mammalian cell state transition

2020-03-25

Abstract excerpt

In the mammalian embryo, epiblast cells must exit their naïve state and acquire formative pluripotency. This cell state transition is recapitulated by mouse embryonic stem cells (ESCs), which undergo pluripotency progression in defined conditions in vitro . However, our understanding of the molecular cascades and gene-networks involved in the exit from naïve pluripotency remains fragmented. Here we employed a com...

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Identifiers and source

Literature Corpus work: 22908612-3065-5bcb-886b-e1f1c706c3c4
DOI: 10.1101/2020.03.23.000109

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