Article

Single Cell Sequencing Reveals Early PGC-like Intermediates During Mouse Primed to Naïve Transition

2021-02-23

Abstract excerpt

<title>Abstract</title> <p>Single cell analysis provides clarity unattainable with bulk approaches. Here we apply single cell RNA-seq to a newly established BMP4 induced mouse primed to naive transition (Bi-PNT) system and show that the reset is not a direct reversal of cell fate but through developmental intermediates. We first show that mEpiSCs bifurcate into c-Kit+ naïve and c-Kit- placenta-like cells, among w...

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Literature Corpus work: b08e86a9-5561-5eb6-888f-32b47dc3444e
DOI: 10.21203/rs.3.rs-151340/v1

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