Article

Scalable primordial germ cell-like-cell platform for functional genomics identifies epigenetic fertility modifiers

2024-02-15

Abstract excerpt

Primordial germ cells (PGCs) are the founder cells of the germline. The ability to generate PGC-like cells (PGCLCs) from pluripotent stem cells has advanced our knowledge of gametogenesis and holds promise for developing infertility treatments. However, generating an ample supply of PGCLCs for demanding applications such as large-scale genetic screens has been a limitation. Here, we demonstrated that simultaneous...

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Literature Corpus work: ad32e136-d116-5160-9c1d-41257bb728c6
DOI: 10.1101/2024.02.15.580543

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