Article

Novel cell states arise in embryonic cells devoid of key reprogramming factors

2024-05-14

Abstract excerpt

<h4>Summary</h4> The capacity for embryonic cells to differentiate relies on a large-scale reprogramming of the oocyte and sperm nucleus into a transient totipotent state. In zebrafish, this reprogramming step is achieved by the pioneer factors Nanog, Pou5f3, and Sox19b (NPS). Yet, it remains unclear whether cells lacking this reprogramming step are directed towards wild type states or towards novel developmental...

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Literature Corpus work: 9ef8dfe5-98de-5f6d-9cc2-cd2b48633526
DOI: 10.1101/2024.05.13.593729

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