Article

Loss of FANCM impairs primordial germ cell differentiation <i>in vitro</i>

2026-02-10

Abstract excerpt

Pathogenic variants in FANCM have been implicated in premature ovarian insufficiency, suggesting a critical role for FANCM in early germline development. To investigate this gene’s function in a controlled system, we evaluated whether a mouse in vitro primordial germ cell (PGC) model could be used to interrogate the consequences of FANCM loss on germ cell specification. Using CRISPR-Cas9 gene editing, we introdu...

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Literature Corpus work: dc9c7a87-3d3a-5557-9aa1-8b0bbf47d6f0
DOI: 10.64898/2026.02.09.704790

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