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Article

Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors.

Cell reports - 24 Dec 2019

Chen Di, Sun Na, Hou Lei, Kim Rachel, Faith Jared, Aslanyan Marianna, Tao Yu, Zheng Yi, Fu Jianping, Liu Wanlu, Kellis Manolis, Clark Amander

Abstract excerpt

In vitro gametogenesis is the process of making germline cells from human pluripotent stem cells. The foundation of this model is the quality of the first progenitors called primordial germ cells (PGCs), which in vivo are specified during the peri-implantation window of human development. Here, we show that human PGC (hPGC) specification begins at day 12 post-fertilization. Using single-cell RNA sequencing of...

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Identifiers

PMID: 31875561
DOI: 10.1016/j.celrep.2019.11.083
PMCID: PMC6939677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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