Article

Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral Synucleinopathy

2024-09-30

Abstract excerpt

<h4>ABSTRACT</h4> A pathological role of alpha-Synuclein (aSyn) aggregation in the central nervous system (CNS) is a recognized feature in Parkinson disease (PD) and related neurodegenerative conditions termed synucleinopathies. In order to characterize the cellular response in CNS to incipient and advanced aSyn pathology, we applied spatial transcriptomics on brain sections derived from a transgenic mouse model...

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Literature Corpus work: 71be46eb-5c4f-5da4-97a0-215c5a50d407
DOI: 10.1101/2024.09.27.615378

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Molecular signatures of altered energy metabolism and circadian rhythm perturbations in a model of extra-nigral SynucleinopathyDOI 10.1101/2024.09.27.615378Read

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