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Article

A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.

Journal of Parkinson's disease - 1 Jan 2000

Polinski Nicole K

Abstract excerpt

The use of wildtype recombinant alpha-synuclein preformed fibrils (aSyn PFFs) to induce endogenous alpha-synuclein to form pathological phosphorylation and trigger neurodegeneration is a popular model for studying Parkinson's disease (PD) biology and testing therapeutic strategies. The strengths of this model lie in its ability to recapitulate the phosphorylation/aggregation of aSyn and nigrostriatal degeneration...

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Identifiers

PMID: 34486988
DOI: 10.3233/JPD-212847
PMCID: PMC8609716

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