Article

Multiparametric MRI and imaging transcriptomics reveal molecular and cellular correlates of neurodegeneration in experimental parkinsonism

2025-11-13

Abstract excerpt

<h4>ABSTRACT</h4> Multiple system atrophy (MSA) is an atypical Parkinsonian disorder marked by oligodendroglial α-synucleinopathy and selective neurodegeneration. Although MRI can capture regional atrophy and microstructural alterations in MSA brain, the molecular substrates underlying these phenotypes remain poorly defined. Imaging transcriptomics provides a computational framework to relate spatial imaging patt...

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Literature Corpus work: 493ad3ba-6b88-555d-9569-3af0b4effb67
DOI: 10.1101/2025.11.12.688033

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