Article

Multi-omics comparative analyses of synucleinopathy models reveal distinct targets and relevance for drug development

2025-06-25

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The discovery and development of therapeutics for Parkinson’s disease (PD) requires preclinical models and an understanding of the disease mechanisms reflected in each model is crucial to success. <h4>Objective</h4> To illuminate disease mechanisms and translational value of two commonly utilized rat models of synucleinopathy – AAV-delivered human mutant hA53T alpha synucle...

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Literature Corpus work: 153b33c2-4c4a-5d62-9c73-4abec479aee4
DOI: 10.1101/2025.06.20.660336

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