Article

Imaging spatial transcriptomics reveals molecular patterns of vulnerability to pathology in a transgenic α-synucleinopathy model

2024-08-01

Abstract excerpt

In Parkinson’s disease and dementia with Lewy bodies, aggregated and phosphorylated α-synuclein pathology appears in select neurons throughout cortical and subcortical regions, but little is currently known about why certain populations are selectively vulnerable. Here, using imaging spatial transcriptomics (IST) coupled with downstream immunofluorescence for α-synuclein phosphorylated at Ser129 (pSyn) in the same...

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Literature Corpus work: fb3a1372-6e4a-5c4a-b7db-805aef5b21b9
DOI: 10.1101/2024.07.31.606032

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