Article

α-Synuclein pathology in Parkinson disease activates homeostatic NRF2 anti-oxidant response

2021-04-15

Abstract excerpt

<h4>ABSTRACT</h4> Circumstantial evidence points to a pathological role of alpha-synuclein (aSyn; gene symbol SNCA ), conferred by aSyn misfolding and aggregation, in Parkinson disease (PD) and related synucleionpathies. Several findings in experimental models implicate perturbations in the tissue homeostatic mechanisms triggered by pathological aSyn accumulation, including impaired redox homeostasis, as signifi...

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Literature Corpus work: 0ceb5004-56b1-5012-9f80-b41b788ded9d
DOI: 10.1101/2021.04.15.439988

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