Article

Spatiotemporal transcriptomic profiling reveals metabolic dysfunction prior to overt tauopathy in the PS19 mouse model

2025-07-10

Abstract excerpt

<title>Abstract</title> <p>Abnormal accumulation of hyperphosphorylated tau in neurofibrillary tangles is a hallmark of neurodegenerative diseases, such as Alzheimer’s disease (AD) and frontotemporal dementia. In AD, tangle pathology characteristically develops in brain regions with heightened vulnerability, such as the entorhinal cortex and hippocampus. Emerging evidence implicates mitochondrial dysfunction and...

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Literature Corpus work: df9e8d7f-9baf-5f17-a0e1-e1dd0bd3779f
DOI: 10.21203/rs.3.rs-6941464/v1

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