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Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregation

2025-01-25

Abstract excerpt

Cortical dysfunction is increasingly recognized as a major contributor to the non-motor symptoms associated with Parkinson’s disease (PD) and other synucleinopathies. Although functional alterations in cortical circuits have been observed in preclinical PD models, the underlying molecular mechanisms are unclear. To bridge this knowledge gap, we investigated tissue-level changes in the cortices of rats and mice tre...

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Literature Corpus work
67f360fe-9638-50d0-b745-0004e857ede4
DOI
10.1101/2025.01.24.634820
Open publication

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Phosphoproteome modifications and cortical circuit dysfunction are linked to the early-stage progression of alpha-synuclein aggregationDOI 10.1101/2025.01.24.634820
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