Article

α-Synuclein pathology disrupts mitochondrial function in dopaminergic and cholinergic neurons at-risk in Parkinson’s disease

2023-12-11

Abstract excerpt

<h4>Background</h4> Pathological accumulation of aggregated α-synuclein (aSYN) is a common feature of Parkinson’s disease (PD). However, the mechanisms by which intracellular aSYN pathology contributes to dysfunction and degeneration of neurons in the brain are still unclear. A potentially relevant target of aSYN is the mitochondrion. To test this hypothesis, genetic and physiological methods were used to monitor...

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Literature Corpus work: 67b26332-e569-56d1-a4a9-9d3edb6da7ae
DOI: 10.1101/2023.12.11.571045

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