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Article

A New Synuclein-Transgenic Mouse Model for Early Parkinson's Reveals Molecular Features of Preclinical Disease.

Molecular neurobiology - 1 Feb 2021

Hendrickx Diana M, Garcia Pierre, Ashrafi Amer, Sciortino Alessia, Schmit Kristopher J, Kollmus Heike, Nicot Nathalie, Kaoma Tony, Vallar Laurent, Buttini Manuel, Glaab Enrico

Abstract excerpt

Understanding Parkinson's disease (PD), in particular in its earliest phases, is important for diagnosis and treatment. However, human brain samples are collected post-mortem, reflecting mainly end-stage disease. Because brain samples of mouse models can be collected at any stage of the disease process, they are useful in investigating PD progression. Here, we compare ventral midbrain transcriptomics profiles...

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alpha-Synuclein
Corpus Striatum
Gene Ontology
Gene Regulatory Networks
Nerve Degeneration

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Parkinson Disease

Substantia Nigra

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Identifiers

PMID: 32997293
DOI: 10.1007/s12035-020-02085-z
PMCID: PMC8219584

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