Article

α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic Challenges

2025-04-25

Abstract excerpt

Parkinson's disease and related synucleinopathies, including dementia with Lewy bodies and multiple system atrophy, are characterized by the pathological aggregation of the α-synuclein (aSyn) protein in neuronal and glial cells, leading to cellular dysfunction and neurodegeneration. This review synthesizes knowledge on aSyn biology, including its structure, aggregation mechanisms, cellular interactions, and s...

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Literature Corpus work: 55b6aa4e-3490-5902-a449-fce78afad229
DOI: 10.20944/preprints202504.2181.v1

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