Article

DNA elements tether canonical Polycomb Repressive Complex 1 to human genes

2023-01-12

Abstract excerpt

<h4>ABSTRACT</h4> Development of multicellular animals requires epigenetic repression by Polycomb group proteins. The latter assemble in multi-subunit complexes, of which two kinds, Polycomb Repressive Complex 1 (PRC1) and Polycomb Repressive Complex 2 (PRC2), act together to effect the repression of key developmental genes. How PRC1 and PRC2 recognize specific genes remains an open question. Here we report syste...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f252a93-dc1a-54f4-9cb7-98ba31019224
DOI: 10.1101/2023.01.12.523763

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

DNA elements tether canonical Polycomb Repressive Complex 1 to human genesDOI 10.1101/2023.01.12.523763Read

From genetics to epigenetics: the tale of Polycomb group and trithorax group genes.Semantic proximity Read

Three classes of response elements for human PRC2 and MLL1/2-trithorax complexesSemantic proximity Read

Epigenetic balance of gene expression by Polycomb and COMPASS families.Semantic proximity Read

Role of polycomb repressive complex 2 in regulation of human transcription factor gene expressionSemantic proximity Read

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb targetsSemantic proximity Read

Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.Semantic proximity Read

Epigenetic control of human HOX clustersSemantic proximity Read

Diversity of Polycomb group complexes in plants: same rules, different players?Semantic proximity Read

Structural assembly of Polycomb group protein and Insight of EZH2 in cancer progression: A review.Semantic proximity Read

Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and CancerSemantic proximity Read

Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblastsSemantic proximity Read

Compositional and functional diversity of canonical PRC1 complexes in mammals.Semantic proximity Read